Acyclovir-d4 is a stable isotope labeled form of Acyclovir, a guanosine analogue recognized for its antiviral properties. Acyclovir exhibits potent inhibitory activity against herpes simplex virus types 1 and 2, exhibiting IC50 values of 0.85 μM and 0.86 μM, respectively, as well as effectiveness against varicella-zoster virus. Its mechanism of action involves phosphorylation by viral thymidine kinase, leading to the formation of Acyclovir triphosphate, which interferes with viral DNA polymerization by competing with guanosine triphosphate and causing chain termination. This compound is useful for studying viral infections and therapeutic interventions, particularly in the context of acute leukemia treatment.
Acyclovir-d4 is a stable isotope labeled form of Acyclovir, a guanosine analogue recognized for its antiviral properties. Acyclovir exhibits potent inhibitory activity against herpes simplex virus types 1 and 2, exhibiting IC50 values of 0.85 μM and 0.86 μM, respectively, as well as effectiveness against varicella-zoster virus. Its mechanism of action involves phosphorylation by viral thymidine kinase, leading to the formation of Acyclovir triphosphate, which interferes with viral DNA polymerization by competing with guanosine triphosphate and causing chain termination. This compound is useful for studying viral infections and therapeutic interventions, particularly in the context of acute leukemia treatment.
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