Fig. 1 · Structure
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Acyclovir-d4
Stable Isotope
Acyclovir-d4 is a stable isotope labeled form of Acyclovir, a guanosine analogue recognized for its antiviral properties. Acyclovir exhibits potent inhibitory activity against herpes simplex virus types 1 and 2, exhibiting IC50 values of 0.85 μM and 0.86 μM, respectively, as well as effectiveness against varicella-zoster virus. Its mechanism of action involves phosphorylation by viral thymidine kinase, leading to the formation of Acyclovir triphosphate, which interferes with viral DNA polymerization by competing with guanosine triphosphate and causing chain termination. This compound is useful for studying viral infections and therapeutic interventions, particularly in the context of acute leukemia treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1185179-33-2 |
| Applications | Stable Isotope |
| Formula | C8H7D4N5O3 |
| Molecular Weight | 229.23 |
| Synonyms | Aciclovir-d4; Acycloguanosine-d4 |
| SMILES | O=C1NC(N)=NC2=C1N=CN2COC([2H])([2H])C([2H])([2H])O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.