Aditoprime is a selective inhibitor of bacterial dihydrofolate reductase (DHFR), demonstrating IC50 values of 47 nM and 520 nM for E. coli and L. casei DHFR, respectively. By inhibiting the conversion of dihydrofolic acid to tetrahydrofolic acid, Aditoprime effectively impairs bacterial folate synthesis. This compound exhibits broad-spectrum antibacterial activity and possesses favorable pharmacokinetic properties, making it a useful reagent in microbiological research and antibiotic development studies.
Aditoprime is a selective inhibitor of bacterial dihydrofolate reductase (DHFR), demonstrating IC50 values of 47 nM and 520 nM for E. coli and L. casei DHFR, respectively. By inhibiting the conversion of dihydrofolic acid to tetrahydrofolic acid, Aditoprime effectively impairs bacterial folate synthesis. This compound exhibits broad-spectrum antibacterial activity and possesses favorable pharmacokinetic properties, making it a useful reagent in microbiological research and antibiotic development studies.
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