ADX68692 is a selective negative allosteric modulator of the follicle-stimulating hormone (FSH) receptor, exhibiting a log IC50 of -5.71. This compound effectively inhibits hCG-induced cAMP production and β-arrestin 2 recruitment in HEK293 cells. ADX68692 demonstrates partial efficacy in mLTC-1 and primary rat Leydig cells, leading to reduced FSHR-mediated cAMP, progesterone, and estradiol production. Additionally, it has been shown to decrease the number of oocytes recovered from the ampullae, making it a valuable tool for studying reproductive biology and hormonal regulation.
ADX68692 is a selective negative allosteric modulator of the follicle-stimulating hormone (FSH) receptor, exhibiting a log IC50 of -5.71. This compound effectively inhibits hCG-induced cAMP production and β-arrestin 2 recruitment in HEK293 cells. ADX68692 demonstrates partial efficacy in mLTC-1 and primary rat Leydig cells, leading to reduced FSHR-mediated cAMP, progesterone, and estradiol production. Additionally, it has been shown to decrease the number of oocytes recovered from the ampullae, making it a valuable tool for studying reproductive biology and hormonal regulation.
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