AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
Cell Research
Cell Line
Type
Value
Description
References
Product Information
Catalog Num
A13131
Formula
C14H17IN4O2
Molecular Weight
400.21
CAS Number
865305-30-2
SMILES
CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC
Synonyms
AF353, AF 353
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro
DMSO
86 mg/mL (214.88 mM)
Water
Insoluble
Ethanol
3 mg/mL (7.49 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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