AF-353

Catalog No.: A13131

P2X3/P2X2/3 receptor antagonist

AF-353

AF-353 Chemical Structure

CAS NO. 865305-30-2

AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
25 mg
$350.00
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Biological Activity

AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
In vitro DMSO 86 mg/mL (214.88 mM)
Water Insoluble
Ethanol 3 mg/mL (7.49 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.99 mL 124.93 mL 249.87 mL
0.5 mM 5 mL 24.99 mL 49.97 mL
1 mM 2.5 mL 12.49 mL 24.99 mL
5 mM 0.5 mL 2.5 mL 5 mL

*The above data is based on the productmolecular weight 400.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13131
Actions Antagonist
CAS No. 865305-30-2
Formula C14H17IN4O2
M. Wt 400.21
Purity >98%
Synonyms AF353, AF 353
SMILES CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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