AF-353

Catalog No.: A13131

P2X3/P2X2/3 receptor antagonist

AF-353 Chemical Structure

CAS NO. 865305-30-2

AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
25 mg
$350.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.99 mL 124.93 mL 249.87 mL
0.5 mM 5 mL 24.99 mL 49.97 mL
1 mM 2.5 mL 12.49 mL 24.99 mL
5 mM 0.5 mL 2.5 mL 5 mL

*The above data is based on the productmolecular weight 400.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13131
Actions Antagonist
M. Wt 400.21
Formula C14H17IN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 865305-30-2
Synonyms AF353, AF 353
SMILES CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC

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