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AF-353

P2X3/P2X2/3 receptor antagonist

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Catalog No. A13131

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AF-353 5mg A13131-5
$90.00
AF-353 10mg A13131-10
$160.00
AF-353 25mg A13131-25
$350.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).

AF-353

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Chemical Information

Catalog Num A13131
Actions Antagonist
M. Wt 400.21
Formula C14H17IN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 865305-30-2
Synonyms AF353, AF 353
SMILES CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC

Biological Activity

Description
AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.99 mL 124.93 mL 249.87mL
0.5 mM 5 mL 24.99 mL 49.97 mL
1 mM 2.5 mL 12.49 mL 24.99 mL
5 mM 0.5 mL 2.5 mL 5 mL

*The above data is based on the productmolecular weight 400.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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