Afatinib impurity 11 is an impurity associated with Afatinib, a well-known irreversible inhibitor of the epidermal growth factor receptor (EGFR) family. Afatinib exhibits potent biological activity, with IC50 values of 0.5 nM, 0.4 nM, 10 nM, and 14 nM against wild-type EGFR, EGFRL858R, EGFRL858R/T790M, and HER2, respectively. This compound is essential for investigating the purity and synthesis of Afatinib, contributing to research focused on targeted cancer therapies.
Afatinib impurity 11 is an impurity associated with Afatinib, a well-known irreversible inhibitor of the epidermal growth factor receptor (EGFR) family. Afatinib exhibits potent biological activity, with IC50 values of 0.5 nM, 0.4 nM, 10 nM, and 14 nM against wild-type EGFR, EGFRL858R, EGFRL858R/T790M, and HER2, respectively. This compound is essential for investigating the purity and synthesis of Afatinib, contributing to research focused on targeted cancer therapies.
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