AG-270 is a first-in-class, reversible, and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor. It functions as an allosteric and noncompetitive inhibitor, with an IC₅₀ of 14 nM. AG-270 is being explored for its therapeutic potential in cancers with MTAP deletions, where MAT2A inhibition leads to selective antitumor effects via disruption of methylation-dependent processes.
AG-270 is a first-in-class, reversible, and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor. It functions as an allosteric and noncompetitive inhibitor, with an IC₅₀ of 14 nM. AG-270 is being explored for its therapeutic potential in cancers with MTAP deletions, where MAT2A inhibition leads to selective antitumor effects via disruption of methylation-dependent processes.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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