AGF347 is a potent multi-targeted antifolate that primarily inhibits serine hydroxymethyltransferase (SHMT)2 in mitochondria and SHMT1 in the cytosol, thereby disrupting de novo purine biosynthesis. This compound induces apoptosis, inhibits mTOR signaling, reduces glutathione (GSH) levels, and increases reactive oxygen species (ROS). AGF347 effectively inhibits the proliferation of both Cisplatin-sensitive and resistant epithelial ovarian cancer (EOC) cells and demonstrates significant antitumor efficacy in SKOV3 EOC xenograft mouse models, making it a valuable tool for ovarian cancer research.
AGF347 is a potent multi-targeted antifolate that primarily inhibits serine hydroxymethyltransferase (SHMT)2 in mitochondria and SHMT1 in the cytosol, thereby disrupting de novo purine biosynthesis. This compound induces apoptosis, inhibits mTOR signaling, reduces glutathione (GSH) levels, and increases reactive oxygen species (ROS). AGF347 effectively inhibits the proliferation of both Cisplatin-sensitive and resistant epithelial ovarian cancer (EOC) cells and demonstrates significant antitumor efficacy in SKOV3 EOC xenograft mouse models, making it a valuable tool for ovarian cancer research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
