Agomelatine-d3 is a deuterium-labeled derivative of Agomelatine, which primarily targets MT1 and MT2 melatonin receptors, demonstrating high affinity with Ki values of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2 cells, respectively. Additionally, Agomelatine acts as a selective antagonist of the 5-HT2C receptor with pKi values of 6.4 and 6.2 for native porcine and cloned human receptors, respectively. This stable isotope compound is valuable for pharmacokinetic studies and metabolic research involving melatonergic modulation and serotonin receptor interactions.
Agomelatine-d3 is a deuterium-labeled derivative of Agomelatine, which primarily targets MT1 and MT2 melatonin receptors, demonstrating high affinity with Ki values of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2 cells, respectively. Additionally, Agomelatine acts as a selective antagonist of the 5-HT2C receptor with pKi values of 6.4 and 6.2 for native porcine and cloned human receptors, respectively. This stable isotope compound is valuable for pharmacokinetic studies and metabolic research involving melatonergic modulation and serotonin receptor interactions.
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