Agomelatine-d4 is a deuterium-labeled analog of Agomelatine, which serves as a selective agonist for the melatonin receptors MT1 and MT2. It exhibits high affinity with Ki values of 0.1 nM, 0.06 nM, 0.12 nM, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Additionally, Agomelatine acts as a selective antagonist of the 5-HT2C receptor, with pKi values of 6.4 and 6.2 at porcine and human cloned 5-HT2C receptors. This stable isotope-labeled reagent is valuable for studies involving melatonin receptor signaling and serotonergic pharmacology.
Agomelatine-d4 is a deuterium-labeled analog of Agomelatine, which serves as a selective agonist for the melatonin receptors MT1 and MT2. It exhibits high affinity with Ki values of 0.1 nM, 0.06 nM, 0.12 nM, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Additionally, Agomelatine acts as a selective antagonist of the 5-HT2C receptor, with pKi values of 6.4 and 6.2 at porcine and human cloned 5-HT2C receptors. This stable isotope-labeled reagent is valuable for studies involving melatonin receptor signaling and serotonergic pharmacology.
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