AK106-001616 is a selective inhibitor of cytosolic phospholipase A2 (cPLA2), exhibiting a potent inhibition with an IC50 of 3.8 nmol/L. This compound effectively reduces the synthesis of pro-inflammatory mediators, including prostaglandins E2 and leukotrienes B4, in stimulated cells. AK106-001616 is valuable for research into inflammatory diseases, neuropathic pain, and pulmonary fibrosis, providing insights into the modulation of inflammatory pathways.
AK106-001616 is a selective inhibitor of cytosolic phospholipase A2 (cPLA2), exhibiting a potent inhibition with an IC50 of 3.8 nmol/L. This compound effectively reduces the synthesis of pro-inflammatory mediators, including prostaglandins E2 and leukotrienes B4, in stimulated cells. AK106-001616 is valuable for research into inflammatory diseases, neuropathic pain, and pulmonary fibrosis, providing insights into the modulation of inflammatory pathways.
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