AM-3189 is a selective agonist of GPR40, with EC50 values of 33 nM in buffer and 10 μM in 100% human serum. This compound enhances glucose-stimulated insulin secretion from pancreatic β cells, offering potential therapeutic applications in type 2 diabetes research. Importantly, AM-3189 shows minimal activity on GPR41, GPR43, and PPAR subtypes, and exhibits low central nervous system penetration. Its efficacy in reducing blood glucose levels has been demonstrated in humanized GPR40 mouse models, making it a valuable tool for metabolic studies.
AM-3189 is a selective agonist of GPR40, with EC50 values of 33 nM in buffer and 10 μM in 100% human serum. This compound enhances glucose-stimulated insulin secretion from pancreatic β cells, offering potential therapeutic applications in type 2 diabetes research. Importantly, AM-3189 shows minimal activity on GPR41, GPR43, and PPAR subtypes, and exhibits low central nervous system penetration. Its efficacy in reducing blood glucose levels has been demonstrated in humanized GPR40 mouse models, making it a valuable tool for metabolic studies.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
