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Biological Activity
AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.98 mL | 99.9 mL | 199.8 mL |
| 0.5 mM | 4 mL | 19.98 mL | 39.96 mL |
| 1 mM | 2 mL | 9.99 mL | 19.98 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
*The above data is based on the productmolecular weight 500.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21612 |
|---|---|
| Actions | Antagonist |
| CAS No. | 1175526-27-8 |
| Formula | C27H27F3N2O4 |
| M. Wt | 500.51 |
| Purity | >98% |
| Synonyms | AM211 free acid, AM 211, AM-211 |
| SMILES | O=C(O)CC1=CC(C2=CC=C(C(F)(F)F)C=C2CN(CC)C(NCC3=CC=CC=C3)=O)=C(OC)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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