Catalog No.
Product Name
Application
Product Information
Citations
- Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.
- Hang Dong, .et al. , Int J Nanomedicine, 2023, 18: 3577-3593 PMID: 37409026
- Baharak Bahmani, .et al. , Nat Commun, 2021, Mar 31;12(1):1999 PMID: 33790276
- Prostaglandin F2α is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
- Michel R Corboz, .et al. , Prostaglandins Other Lipid Mediat, 2020, Oct 1;152:106486 PMID: 33011365
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CRTh2 Receptor Antagonist
AZ-11665362 is a selective antagonist of the CRTh2 (DP2) receptor, exhibiting a potent IC50 of 2.6 nM. While it demonstrates slight activity towards aldose reductase and the serotonin transporter, it shows negligible inhibition of COX-1 and COX-2 enzymes. This compound is primarily utilized in research focused on asthma and other inflammatory diseases, providing valuable insights into therapeutic pathways targeting eosinophilic inflammation. -
mast cell stabilizer
Nedocromil is a medication considered as mast cell stabilizer which act to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade. - PDC31 (THG113.31; ILGHXDYK) is an allosteric and non-competitive inhibitor of FP Prostaglandin Receptor. PDC31 is the D-amino acid-based oligopeptide, is used for smooth muscle contractile agent. PDC31 decreases the strength and duration of uterine contractions in vivo, which can be used for research of preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca2+-dependent large-conductance K+-channel in human myometrial cells.
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prostaglandin synthase inhibitor
Pizuglanstat is a hematopoietic prostaglandin synthase inhibitor. -
Prostaglandin E2 Inhibitor
Thielavin B is an inhibitor of prostaglandin biosynthesis, specifically targeting the synthesis of prostaglandin E2 from endoperoxide precursors. This compound demonstrates significant anti-inflammatory activity, as evidenced by its efficacy in reducing carrageenan-induced edema in rat models following intravenous administration. Thielavin B is valuable for research focused on inflammation and pain pathways. -
Prostaglandin Receptor Antagonist
AL-8810 is a potent and selective antagonist of the prostaglandin F2α (PGF2α) receptor (FP receptor), with Ki values of 0.2 ± 0.06 μM in mouse 3T3 cells and 0.4 ± 0.1 μM in rat A7r5 cells. In addition to its antagonistic activity, AL-8810 also activates MAPK and ERK1/2 signaling pathways. It is commonly used in research related to elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG). -
CRTH2 Receptor Antagonist
CT-133 is a selective and potent antagonist of the CRTH2 receptor, exhibiting a Ki value of 2.2 nM, while demonstrating minimal affinity for the DP1 receptor (Ki > 3800 nM). This compound effectively inhibits neutrophil migration induced by PGD2 and has been shown to significantly reduce lung inflammation and improve lung function in a mouse model of acute lung injury (ALI) triggered by cigarette smoke. Additionally, CT-133 suppresses the overexpression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, and promotes the recovery of the anti-inflammatory cytokine IL-10. CT-133 is valuable for research on acute lung injury and inflammatory responses. -
TXA2 Agonist
U-46619 is a stable analogue of Thromboxane A2 (TXA2) that functions as a potent TXA2 receptor (TP) agonist. This compound also acts as a RhoA agonist, promoting RhoA activation through TXA2 receptor engagement. U-46619 is primarily utilized in research to study thromboxane signaling and its implications in cardiovascular and inflammatory responses. Its ability to selectively activate TXA2 pathways makes it an essential tool for investigating related biological processes. -
Prostaglandin
Prostaglandin D2 (PGD2) is an endogenous lipid mediator primarily involved in sleep promotion and the modulation of inflammatory responses. It is produced in various mammalian brains and is recognized for its potent ability to induce sleep and reduce inflammatory processes. PGD2 is valuable in research applications related to sleep disorders, neurobiology, and inflammation. -
Thromboxane-Prostaglandin Receptor Antagonist
Terutroban sodium is a selective and orally active thromboxane-prostaglandin (TP) receptor antagonist, exhibiting an IC50 value of 16.4 nM. This compound effectively inhibits the activity of thromboxane A2 (TXA2) and prostaglandin endoperoxide receptors, demonstrating potent antithrombotic effects. Terutroban sodium also possesses anti-atherosclerotic and anti-vasoconstrictor properties, making it valuable for research applications in cardiovascular disease and related areas. -
PGDS Inhibitor
2-Benzoylthiophene is a selective inhibitor of human hematopoietic prostaglandin D2 synthase (H-PGDS), exhibiting an IC50 value of 11.4 μM. This compound is valuable for investigating the role of prostaglandin D2 in inflammatory diseases and related research applications. Its inhibitory action on H-PGDS provides a useful tool for exploring therapeutic strategies targeting inflammatory pathways. -
EP3 Receptor Antagonist
L-798106 is a potent and highly selective antagonist of the prostanoid EP3 receptor, exhibiting a Ki value of 0.3 nM. While it demonstrates micromolar activity at the EP4 receptor with a Ki of 916 nM, it shows minimal binding affinities at the EP1 and EP2 receptors, with Ki values exceeding 5000 nM. This compound is valuable for research applications involving the modulation of EP3 receptor-mediated pathways and investigating the role of prostanoids in various physiological processes. -
EP4 Receptor Agonist
L-902688 is a potent and selective agonist of the EP4 receptor, exhibiting a Ki value of 0.38 nM and an EC50 of 0.6 nM. This compound demonstrates greater than 4,000-fold selectivity for EP4 compared to other EP and prostanoid receptors. It serves as a valuable tool for researchers investigating the role of EP4 in various biological processes and potential therapeutic applications related to inflammation and pain management. -
EP4 Receptor Antagonist
L-161982 is a selective antagonist of the EP4 receptor, effectively inhibiting the biological activity of prostaglandin E2 (PGE2). It demonstrates complete blockade of PGE2-induced ERK phosphorylation and suppresses cell proliferation in HCA-7 cells. In addition, L-161982 has been shown to reduce symptoms of collagen-induced arthritis in murine models, making it a valuable tool for studying inflammatory pathways and potential therapeutic interventions in arthritis research. -
EP2 Receptor Agonist
Omidenepag is a selective, non-prostanoid agonist of the EP2 receptor, exhibiting an EC50 of 1.1 nM. With an IC50 value of 10 nM for the human EP2 receptor, Omidenepag plays a crucial role in studying conditions associated with intraocular pressure. Its potent biological activity makes it a valuable tool for research into ocular diseases and related pathophysiological mechanisms. -
Vasodilator
Beraprost sodium is a stable, orally active prostacyclin analog that acts as a potent vasodilator. By expanding renal blood vessels and enhancing microcirculation, it holds potential for the treatment of pulmonary arterial hypertension. Additionally, Beraprost sodium features an alkyne group, enabling its use as a click chemistry reagent that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various biochemical applications. -
EP3 Receptor Agonist
Ricinoleic acid is a hydroxylated fatty acid and a potent agonist of the prostaglandin EP3 receptor, with an EC50 of 0.5 μM in MEG-01 cells. This compound is associated with various biological activities, including laxative effects and uterine contractions. Additionally, ricinoleic acid demonstrates both antianxiety-like and anti-inflammatory properties, making it valuable for research in pharmacology and developmental biology. Its high purity (≥99%) enhances its suitability for diverse applications, including studies related to gastrointestinal function and reproductive health. -
EP4 Antagonist
EP4 receptor antagonist 1 is a highly potent and selective competitive antagonist of the prostanoid EP4 receptor, primarily utilized in cancer immunotherapy. It exhibits strong inhibition of human and mouse EP4 receptors with IC50 values of 6.1 nM and 16.2 nM, respectively, while showing minimal activity against human EP1, EP2, and EP3 receptors, with IC50s exceeding 10 μM. This specificity makes it a valuable tool for investigating the role of EP4 in various oncological processes. -
PGD2 receptor Agonist
Prostaglandin J2 (PGJ2) is a potent agonist of the PGD2 receptors, notably hDP and hCRTH2, exhibiting Kis of 0.9 nM and 6.6 nM, respectively. It effectively stimulates intracellular cyclic AMP production with an EC50 of 1.2 nM. Beyond its receptor activity, Prostaglandin J2 is implicated in inducing oxidative stress, neuronal apoptosis, and the accumulation of ubiquitinated proteins. Its neurotoxic properties suggest a potential role in the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's. This compound is valuable for research into receptor signaling pathways and neurodegenerative mechanisms. -
Prostaglandin Receptor Inhibitor
p-Hydroxycinnamic acid is a prostaglandin receptor inhibitor that functions as a dietary phenolic compound. It demonstrates significant biological activity by inhibiting platelet activity, with IC50 values of 371 μM for thromboxane B2 production and 126 μM for lipopolysaccharide-induced prostaglandin E2 generation. This compound is often utilized in research related to inflammation, cardiovascular diseases, and platelet function studies. -
Prostacyclin Agonist
ONO 1301 is a potent prostacyclin agonist that mimics the action of prostaglandin I2. It exhibits thromboxane-synthase inhibitory activity, enhancing the production of hepatocyte growth factor (HGF) from multiple cell types. Research demonstrates that ONO 1301 effectively ameliorates ischemia-induced left ventricular dysfunction in various animal models, including mouse, rat, and pig, making it a valuable tool for studies related to cardiovascular health and regenerative medicine. -
EP1 Antagonist
SC-51322 is a selective antagonist of the prostaglandin E2 receptor subtype EP1, exhibiting a pA2 value of 8.1. This compound demonstrates significant analgesic properties, making it a valuable tool for research focused on pain mechanisms and inflammation. Its specificity for the EP1 receptor allows for the exploration of pathways involved in nociception and potential therapeutic interventions. -
EP4 Agonist
Rivenprost is a selective agonist of the prostaglandin E receptor EP4, characterized by a Ki value of 0.7 nM. It has demonstrated hepatoprotective properties and bone anabolic activity. This compound is relevant for research in areas such as liver protection, bone metabolism, and the pharmacological modulation of EP4 receptor activity. -
EP2 Receptor Agonist
Omidenepag isopropyl is a selective agonist of the EP2 receptor. Upon corneal penetration, it is converted to the active form, Omidenepag, which demonstrates high selectivity for the EP2 receptor with minimal affinity for EP1 and FP receptors. This compound is under investigation for its potential use in lowering intraocular pressure, making it a valuable candidate for glaucoma treatment research. -
Prostaglandin Derivative
Thromboxane B2 is a prostaglandin derivative primarily involved in inducing arterial contraction and promoting platelet aggregation. This biological inactive product serves as a circulating catabolite of thromboxane A2, making it relevant as a diagnostic marker for angina in both peripheral venous and coronary sinus blood. Research indicates that Thromboxane B2 levels correlate with COX-1 activity inhibition in platelets. Furthermore, in preclinical models, Thromboxane B2 has demonstrated dose-dependent effects on respiratory function, producing decreases in airflow rate and dynamic lung compliance while increasing pulmonary airway resistance, highlighting its role as a bronchoactive metabolite in the arachidonic acid bioconversion pathway. -
CRTH2/DP Receptors Dual Antagonist
Vidupiprant is a phenylacetic acid derivative that acts as a dual antagonist of CRTH2 (DP2) and prostanoid D receptors (DP1). It exhibits high potency with IC50 values of 3 nM and 4 nM in buffer, and 8 nM and 35 nM in human plasma, respectively. This compound shows promise for therapeutic applications in asthma management and related respiratory conditions. -
TXA2 Receptor Antagonist
NTP42 is a potent thromboxane A2 (TXA2) receptor antagonist, exhibiting an IC50 of 3.278 nM in inhibiting T prostanoid receptor (TP)-mediated [Ca2+] mobilization upon stimulation with the alternative TP agonist U46619. This compound is particularly relevant for research applications targeting pulmonary arterial hypertension (PAH), offering potential therapeutic avenues for addressing this condition through TXA2 modulation. -
Dual Thromboxane Synthase Inhibitor and Receptor Antagonist
Ridogrel is a dual thromboxane A2 synthase inhibitor and receptor antagonist. This compound exhibits potent antiplatelet activity, making it useful in research focused on cardiovascular diseases and thrombotic disorders. Additionally, Ridogrel displays anti-inflammatory properties, providing a valuable tool for studying inflammation-related pathways in various biological contexts. -
Thromboxane-prostanoid (TP) Receptor Antagonist
SQ 29548 is a selective thromboxane-prostanoid (TP) receptor antagonist. This compound inhibits TP receptor signaling, which plays a critical role in various physiological and pathological processes, including vascular function, platelet aggregation, and inflammation. Its primary applications include research in cardiovascular diseases, thrombus formation, and the study of prostanoid biology. SQ 29548 serves as a valuable tool for investigating the therapeutic potential of modulating TP receptor activity. -
EP4 Antagonist
MF-766 is a potent and selective EP4 antagonist, exhibiting a Ki value of 0.23 nM. It functions as a full antagonist in functional assays, displaying an IC50 of 1.4 nM, which slightly increases to 1.8 nM in the presence of 10% human serum. This reagent is valuable for research related to cancer and inflammatory diseases, facilitating the exploration of EP4 pathways in therapeutic contexts. -
Prostaglandin Receptor Inhibitor
Ascorbyl tetra-2-hexyldecanoate is a lipophilic derivative of L-ascorbic acid that functions as a prostaglandin receptor inhibitor. This compound demonstrates protective effects on HaCaT keratinocytes, maintaining cell viability against UVB and oxidative stress while decreasing the production of inflammatory mediators IL-1α and prostaglandin E2 (PGE2). In vivo studies show that topical application enhances epidermal thickness, increases stratum corneum hydration, and improves skin texture, highlighting its potential for formulating skin whitening agents in cosmetic applications. -
EP4 Agonist
TCS 2510 is a selective agonist of the EP4 receptor, known for its potential to modulate various biological processes. This compound exhibits significant activity in the context of metabolic diseases, making it a valuable tool for research applications aimed at understanding the underlying mechanisms of these disorders. -
Active Metabolite of Misoprostol
Misoprostol acid is the active metabolite of Misoprostol, a synthetic analogue of prostaglandin E1 (PGE1). This compound is rapidly formed through de-esterification in the gastrointestinal tract following oral administration and is effective in preventing non-steroidal anti-inflammatory drug-induced gastric ulcers. Additionally, Misoprostol acid plays a significant role in obstetric applications, particularly in the induction of labor. -
EP3 Receptor Agonist
Sulprostone is a potent and selective agonist of the EP3 receptor, a critical target in various physiological processes. This prostaglandin E2 (PGE2) analog exhibits antiulcer and nonsteroidal abortifacient properties. Sulprostone is relevant for research applications focused on pregnancy termination and the management of hemorrhages during delivery. -
Prostaglandin Receptor Agonist
ONO-AE 248 is a selective agonist of the EP3 prostaglandin receptor, exhibiting notable cardioprotective properties. It significantly reduces myocardial infarction size by specifically targeting the EP3α receptor in murine models, with its beneficial effects occurring independently of hemodynamic changes. The protective mechanism may involve the activation of protein kinase C and the opening of K(ATP) channels, highlighting its potential utility in cardiovascular research. -
TxA2 Synthase/Receptor Inhibitor
Picotamide is a dual inhibitor of thromboxane A2 (TxA2) synthase and its receptor, exhibiting significant antiplatelet activity. This compound is effective in reducing microalbuminuria and inhibiting the growth of carotid plaques, particularly in diabetic models. Picotamide is a valuable tool for investigating both acute and chronic cardiovascular diseases, aiding research into therapeutic interventions for these conditions. -
EP3 Antagonist
EP3 antagonist 3 is a potent and selective antagonist of the EP3 receptor, exhibiting a pKi value of 8.3. This compound demonstrates excellent pharmacokinetic properties, making it suitable for in vivo studies. EP3 antagonist 3 is primarily utilized in research related to overactive bladder (OAB), providing valuable insights into potential therapeutic interventions. -
EP1 Antagonist
SC 51089 free base acts as a selective antagonist of the prostaglandin E2 EP1 receptor, displaying inhibitory constants (Kis) of 1.3 μM for EP1, 11.2 μM for TP, 17.5 μM for EP3, and 61.1 μM for FP receptors. This compound demonstrates notable neuroprotective activity, making it valuable for research in neurobiology and inflammation studies. Its specificity towards the EP1 receptor positions SC 51089 free base as an important tool for investigating the effects of prostaglandin signaling in various biological systems. -
EP2 Inhibitor
TG8-260 is a selective EP2 antagonist designed to mitigate the effects of inflammation in both central nervous system and peripheral diseases. This compound effectively reduces neuroinflammation and gliosis in the hippocampus of rats following pilocarpine-induced status epilepticus. With a plasma half-life of 2.14 hours and an oral bioavailability of 77.3%, TG8-260 also demonstrates potent inhibition of CYP450. Its ability to inhibit EP2 receptor-mediated inflammatory gene expression in BV2-hEP2 microglia makes it a valuable tool for investigating anti-inflammatory pathways in various animal models of peripheral inflammatory conditions. -
EP4 Receptor Agonist
EP4 Receptor Agonist 2 is a potent agonist of the EP4 receptor, exhibiting an EC50 value of 0.8 nM. This compound has demonstrated selectivity with Ki values of >100,000, 38,000, and 3.1 nM for the EP2, EP3, and EP4 receptors, respectively. It is a valuable tool for studying the role of EP4 signaling in various biological processes and exploring potential therapeutic applications in inflammatory and cardiovascular diseases. -
TxA2/PGH2 Receptor Antagonist
Ifetroban sodium is an orally active antagonist of the thromboxane A2 (TXA2) and prostaglandin H2 (PGH2) receptors. It exhibits significant antiplatelet activity and effectively inhibits tumor cell migration while having no impact on cell proliferation. This compound is valuable in research related to myocardial ischemia, hypertension, stroke, thrombosis, and cardiomyopathy. -
FP Receptor Agonist
Tafluprost acid is a selective agonist of the prostanoid FP receptor, demonstrating high affinity with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Its binding affinity for the prostanoid EP3 receptor is significantly lower, with an IC50 of 67 nM, indicating a preferential interaction with the FP receptor. Tafluprost acid is primarily utilized in glaucoma research, making it a valuable tool for studies focused on intraocular pressure regulation and ocular pharmacology. -
EP3 Receptor Antagonist
L-826266 is a selective and competitive antagonist of the EP3 receptor. This compound exhibits potent inhibition of EP3-mediated signaling, making it valuable for investigating pathways involved in convulsive disorders and other related conditions. Its targeted mechanism of action supports research into the role of prostaglandin signaling in neuroinflammation and seizure activity. -
EP2 Receptor Antagonist
EP2 receptor antagonist-3 is a selective antagonist of the EP2 receptor, exhibiting an IC50 of 8 nM in human EP2 SPA assays and 50 nM in human EP2 cAMP assays. It enhances macrophage-mediated clearance of Amyloid-β plaques, making it a valuable tool for research into Alzheimer's disease and related neurodegenerative disorders. This compound can aid in understanding the role of EP2 receptors in immune response and amyloid pathology. -
Prostaglandin Receptor Antagonist
BAY-6672 hydrochloride is a potent and selective antagonist of the human Prostaglandin F (FP) receptor, exhibiting an IC50 of 11 nM. This compound is primarily utilized in the research of inflammatory processes and pain modulation, making it valuable for studies in pharmacology and therapeutic development. Its selective action on FP receptors provides insights into prostaglandin signaling pathways and their implications in various pathophysiological conditions. -
Vasodilator
Prostaglandin F1α is a potent vasodilator that primarily targets smooth muscle tissue. It has demonstrated the ability to induce relaxation of vascular smooth muscle, leading to reduced blood pressure. This compound is widely used in cardiovascular research to study its effects on vascular tone and the regulation of blood flow. -
EP2 Antagonist
EP2 Receptor Antagonist-1 is a potent allosteric antagonist of the prostaglandin EP2 receptor, exhibiting reversible binding and agonist-dependent activity. This compound demonstrates significant anti-inflammatory effects, making it valuable for research focusing on inflammatory pathways and conditions. Its ability to selectively inhibit EP2 receptor activity positions it as a useful tool in pharmacological studies aimed at exploring novel therapeutic strategies.
