AM281 is a selective antagonist of the cannabinoid receptor type 1 (CB1) with an IC50 value of 9.91 nM. This compound exhibits significant potency in inhibiting the CB1 receptor, while demonstrating a much lower affinity for the CB2 receptor with an IC50 of 13,000 nM. AM281 is primarily utilized in research applications related to endocannabinoid signaling, neurobiology, and the potential modulation of disorders involving CB1 receptor activity.
AM281 is a selective antagonist of the cannabinoid receptor type 1 (CB1) with an IC50 value of 9.91 nM. This compound exhibits significant potency in inhibiting the CB1 receptor, while demonstrating a much lower affinity for the CB2 receptor with an IC50 of 13,000 nM. AM281 is primarily utilized in research applications related to endocannabinoid signaling, neurobiology, and the potential modulation of disorders involving CB1 receptor activity.
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