Amelparib is a selective inhibitor of PARP-1, exhibiting potent activity with an IC50 of 18.5 nM for PARP-1 inhibition and 10.7 nM for cellular PAR formation. This orally active and water-soluble compound demonstrates potential neuroprotective effects, making it a valuable tool for research in the field of acute ischemic stroke. Amelparib's ability to modulate PARP-1 activity offers insights into its therapeutic roles in neuroprotection and cellular repair mechanisms.
Amelparib is a selective inhibitor of PARP-1, exhibiting potent activity with an IC50 of 18.5 nM for PARP-1 inhibition and 10.7 nM for cellular PAR formation. This orally active and water-soluble compound demonstrates potential neuroprotective effects, making it a valuable tool for research in the field of acute ischemic stroke. Amelparib's ability to modulate PARP-1 activity offers insights into its therapeutic roles in neuroprotection and cellular repair mechanisms.
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