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AMG 548

p38 MAPK inhibitor

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Catalog No. A10970

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AMG 548 5mg A10970-5
AMG 548 10mg A10970-10
AMG 548 50mg A10970-50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.

AMG 548

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Chemical Information

Catalog Num A10970
Actions Inhibitor
M. Wt 461.56
Formula C29H27N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 864249-60-5
Synonyms AMG-548, AMG548
SMILES O=C1N(C)C(NC[[email protected]](CC2=CC=CC=C2)N)=NC(C3=CC=NC=C3)=C1C4=CC=C5C(C=CC=C5)=C4

Biological Activity

AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.67 mL 108.33 mL 216.66mL
0.5 mM 4.33 mL 21.67 mL 43.33 mL
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL

*The above data is based on the productmolecular weight 461.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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