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AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.67 mL | 108.33 mL | 216.66 mL |
| 0.5 mM | 4.33 mL | 21.67 mL | 43.33 mL |
| 1 mM | 2.17 mL | 10.83 mL | 21.67 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.33 mL |
*The above data is based on the productmolecular weight 461.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10970 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 864249-60-5 |
| Formula | C29H27N5O |
| M. Wt | 461.56 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | AMG-548, AMG548 |
| SMILES | O=C1N(C)C(NC[[email protected]](CC2=CC=CC=C2)N)=NC(C3=CC=NC=C3)=C1C4=CC=C5C(C=CC=C5)=C4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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