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AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
Targets
| PI3Kδ | PI3Kγ | PI3Kβ | PI3Kα | |
| 18 nM | 850 nM | 2.7μM | 33 μM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.95 mL | 129.74 mL | 259.47 mL |
| 0.5 mM | 5.19 mL | 25.95 mL | 51.89 mL |
| 1 mM | 2.59 mL | 12.97 mL | 25.95 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.19 mL |
*The above data is based on the productmolecular weight 385.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15901 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 385.4 |
| Formula | C21H16FN7 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1608125-21-8 |
| Synonyms | AMG-319, AMG 319 |
| SMILES | C[[email protected]@](NC1=NC=NC2=C1N=CN2)([H])C(C=C3C=CC(F)=CC3=N4)=C4C5=CC=CC=N5 |
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