Catalog No.: A15901

PI3Kδ inhibitor


AMG319 Chemical Structure

CAS NO. 1608125-21-8

AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.

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Biological Activity

AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
18 nM850 nM2.7μM33 μM
In vitro DMSO 72 mg/mL (186.82 mM)
Water Insoluble
Ethanol 72 mg/mL (186.82 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.95 mL 129.74 mL 259.47 mL
0.5 mM 5.19 mL 25.95 mL 51.89 mL
1 mM 2.59 mL 12.97 mL 25.95 mL
5 mM 0.52 mL 2.59 mL 5.19 mL

*The above data is based on the productmolecular weight 385.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15901
Actions Inhibitor
CAS No. 1608125-21-8
Formula C21H16FN7
M. Wt 385.4
Purity >98%
Synonyms AMG-319, AMG 319
SMILES C[[email protected]@](NC1=NC=NC2=C1N=CN2)([H])C(C=C3C=CC(F)=CC3=N4)=C4C5=CC=CC=N5

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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