Fig. 1 · Structure
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Aminooxy-PEG1-propargyl
PROTAC Linker
Aminooxy-PEG1-propargyl is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. Featuring an alkyne group, it facilitates click chemistry and can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for precise conjugation with azide-containing molecules. This compound is valuable for researchers engaged in the development of targeted protein degradation strategies. Its versatility makes it an essential tool for advancing chemical biology applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1895922-69-6 |
| Applications | PROTAC Linker |
| Formula | C5H9NO2 |
| Molecular Weight | 115.13 |
| SMILES | NOCCOCC#C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.