Aminooxy-PEG3-C2-thiol is a PEG-derived linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound exhibits the ability to facilitate the conjugation of target proteins with E3 ligases, promoting the selective degradation of unwanted proteins through the ubiquitin-proteasome system. Its application in PROTAC development supports research in targeted protein degradation, with significant implications for therapeutic advancements in various diseases.
Aminooxy-PEG3-C2-thiol is a PEG-derived linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound exhibits the ability to facilitate the conjugation of target proteins with E3 ligases, promoting the selective degradation of unwanted proteins through the ubiquitin-proteasome system. Its application in PROTAC development supports research in targeted protein degradation, with significant implications for therapeutic advancements in various diseases.
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