Amitriptyline-d3 hydrochloride is a deuterium-labeled derivative of amitriptyline, primarily targeting the serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET). It exhibits Ki values of 3.45 nM and 13.3 nM for human SERT and NET, respectively, and demonstrates weak binding to the dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Additionally, amitriptyline-d3 hydrochloride acts as an agonist for TrkA and TrkB receptors, exhibiting neurotrophic activity and contributing to its antidepressant effects. This stable isotope is valuable for metabolic studies and drug mechanism research.
Amitriptyline-d3 hydrochloride is a deuterium-labeled derivative of amitriptyline, primarily targeting the serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET). It exhibits Ki values of 3.45 nM and 13.3 nM for human SERT and NET, respectively, and demonstrates weak binding to the dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Additionally, amitriptyline-d3 hydrochloride acts as an agonist for TrkA and TrkB receptors, exhibiting neurotrophic activity and contributing to its antidepressant effects. This stable isotope is valuable for metabolic studies and drug mechanism research.
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