Fig. 1 · Structure
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AMN082 free base
mGluR7 Agonist
AMN082 free base is a selective mGluR7 agonist that activates receptor signaling through an allosteric site within the transmembrane domain. This compound effectively inhibits cAMP accumulation and promotes GTPγS binding at transfected mammalian cells expressing mGluR7, with EC50 values ranging from 64 to 290 nM. AMN082 free base demonstrates selectivity for mGluR7 over other metabotropic glutamate receptor subtypes and certain ionotropic glutamate receptors, highlighting its potential for research in neuroscience and depression-related studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 83027-13-8 |
| Applications | mGluR7 Agonist |
| Formula | C28H28N2 |
| Molecular Weight | 392.54 |
| SMILES | C(C1=CC=CC=C1)(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.