AMN082 free base is a selective mGluR7 agonist that activates receptor signaling through an allosteric site within the transmembrane domain. This compound effectively inhibits cAMP accumulation and promotes GTPγS binding at transfected mammalian cells expressing mGluR7, with EC50 values ranging from 64 to 290 nM. AMN082 free base demonstrates selectivity for mGluR7 over other metabotropic glutamate receptor subtypes and certain ionotropic glutamate receptors, highlighting its potential for research in neuroscience and depression-related studies.
AMN082 free base is a selective mGluR7 agonist that activates receptor signaling through an allosteric site within the transmembrane domain. This compound effectively inhibits cAMP accumulation and promotes GTPγS binding at transfected mammalian cells expressing mGluR7, with EC50 values ranging from 64 to 290 nM. AMN082 free base demonstrates selectivity for mGluR7 over other metabotropic glutamate receptor subtypes and certain ionotropic glutamate receptors, highlighting its potential for research in neuroscience and depression-related studies.
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