AMN082 is a selective mGluR7 agonist that operates through allosteric activation of the receptor signaling pathway. It effectively inhibits cAMP accumulation and promotes GTPγS binding in transfected mammalian cells, with EC50 values ranging from 64 to 290 nM. AMN082 demonstrates notable selectivity for mGluR7 over other mGluR subtypes and ionotropic glutamate receptors, making it a valuable tool for research into neuropharmacology and potential antidepressant effects.
AMN082 is a selective mGluR7 agonist that operates through allosteric activation of the receptor signaling pathway. It effectively inhibits cAMP accumulation and promotes GTPγS binding in transfected mammalian cells, with EC50 values ranging from 64 to 290 nM. AMN082 demonstrates notable selectivity for mGluR7 over other mGluR subtypes and ionotropic glutamate receptors, making it a valuable tool for research into neuropharmacology and potential antidepressant effects.
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