AMP-579 is an adenosine receptor agonist targeting the adenosine A1 and A2A receptors, exhibiting Ki values of 1.7 nM and 4.5 nM for A1 receptors in rat brain and adipocytes, and a Ki value of 56 nM for A2A receptors in rat brain. This compound effectively inhibits lipolysis and restores insulin-dependent glucose transport through A1 receptor activation, while it promotes vasodilation, especially in coronary arteries, via A2A receptor activation with an IC50 of 0.3 μM in porcine coronary arterial rings. AMP-579 holds potential in cardioprotection and the therapeutic management of acute myocardial infarction.
AMP-579 is an adenosine receptor agonist targeting the adenosine A1 and A2A receptors, exhibiting Ki values of 1.7 nM and 4.5 nM for A1 receptors in rat brain and adipocytes, and a Ki value of 56 nM for A2A receptors in rat brain. This compound effectively inhibits lipolysis and restores insulin-dependent glucose transport through A1 receptor activation, while it promotes vasodilation, especially in coronary arteries, via A2A receptor activation with an IC50 of 0.3 μM in porcine coronary arterial rings. AMP-579 holds potential in cardioprotection and the therapeutic management of acute myocardial infarction.
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