Amphotericin B

Catalog No.: A10073

Amphotericin B Chemical Structure

CAS NO. 1397-89-3

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.

Availability: In stock

Package Price Qty
50 mg
$30.00
100 mg
$45.00
500 mg
$81.00
10mM * 1mL in DMSO
$65.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.
Targets
ergosterol
In vitro DMSO 22 mg/mL (23.8 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.82 mL 54.11 mL 108.21 mL
0.5 mM 2.16 mL 10.82 mL 21.64 mL
1 mM 1.08 mL 5.41 mL 10.82 mL
5 mM 0.22 mL 1.08 mL 2.16 mL

*The above data is based on the productmolecular weight 924.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10073
Actions No
M. Wt 924.1
Formula C47H73NO17
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1397-89-3
Synonyms Fungilin, Fungizone, AmBisome, Fungisome, Amphocil, Amphotec
SMILES C[[email protected]]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[[email protected]@H](C[[email protected]]2[[email protected]@H]([[email protected]](C[[email protected]](O2)(C[[email protected]](C[[email protected]]([[email protected]@H](CC[[email protected]](C[[email protected]](CC(=O)O[[email protected]]([[email protected]@H]([[email protected]@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[[email protected]]3[[email protected]]([[email protected]]([[email protected]@H]([[email protected]](O3)C)O)N)O

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