Androgen Receptor Antagonist 12 is a potent orally active antagonist of the androgen receptor, exhibiting an IC50 of 0.30 μM. It effectively inhibits the transcriptional activity of variant androgen receptor mutants and suppresses the proliferation of androgen receptor-positive prostate cancer cell lines. Additionally, this compound obstructs androgen receptor nuclear translocation and demonstrates tumor growth inhibition in a C4-2B xenograft mouse model. Androgen Receptor Antagonist 12 is a valuable tool for research in prostate cancer biology.
Androgen Receptor Antagonist 12 is a potent orally active antagonist of the androgen receptor, exhibiting an IC50 of 0.30 μM. It effectively inhibits the transcriptional activity of variant androgen receptor mutants and suppresses the proliferation of androgen receptor-positive prostate cancer cell lines. Additionally, this compound obstructs androgen receptor nuclear translocation and demonstrates tumor growth inhibition in a C4-2B xenograft mouse model. Androgen Receptor Antagonist 12 is a valuable tool for research in prostate cancer biology.
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