HIF/HIF Prolyl-Hydroxylase

HIF-1α-IN-7 is a potent inhibitor of hypoxia-inducible factor 1-alpha (HIF-1α), a key regulator of cellular responses to hypoxia. This compound exhibits neuroprotective activity and has potential applications in Alzheimer's disease research, enabling investigations into mechanisms of neurodegeneration and hypoxic responses in neuronal cells.

HIF-2α-IN-9 is a selective inhibitor of HIF-2α, effectively modulating hypoxia-responsive pathways. This compound demonstrates significant inhibition of VEGF-A with an IC50 value of 305 nM, influencing tumor growth and angiogenesis. HIF-2α-IN-9 also promotes reactivation of macrophage-mediated tumor immunity, making it a valuable tool for research in cancer biology and therapeutic approaches targeting tumor microenvironments.

CLB-016 is a potent inhibitor of Hypoxia-inducible factor 1 (HIF-1) with an IC50 of 19.1 µM. This compound effectively suppresses HIF-1-mediated responses to hypoxia, making it a valuable tool for research focused on cellular adaptation to low oxygen conditions. CLB-016 is applicable in studies examining the role of HIF in tumor progression, metabolic regulation, and other hypoxia-related pathologies.