Angiopeptin is a cyclic octapeptide analogue of somatostatin that acts as a partial agonist at the sst2 and sst5 receptors, exhibiting IC50 values of 0.26 nM and 6.92 nM, respectively. This compound effectively inhibits growth hormone secretion and reduces insulin-like growth factor-1 (IGF-1) production. Angiopeptin also modulates cellular signaling by inhibiting adenylate cyclase and stimulating extracellular acidification. Its unique properties make it a valuable tool for research into coronary atherosclerosis and related metabolic disorders.
Angiopeptin is a cyclic octapeptide analogue of somatostatin that acts as a partial agonist at the sst2 and sst5 receptors, exhibiting IC50 values of 0.26 nM and 6.92 nM, respectively. This compound effectively inhibits growth hormone secretion and reduces insulin-like growth factor-1 (IGF-1) production. Angiopeptin also modulates cellular signaling by inhibiting adenylate cyclase and stimulating extracellular acidification. Its unique properties make it a valuable tool for research into coronary atherosclerosis and related metabolic disorders.
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