Anticancer agent 216 (34A) is a Camptothecin derivative that selectively inhibits topoisomerase I, disrupting DNA replication and transcription. It demonstrates potent cytotoxicity with IC50 values of 9.6 nM in MCF-7 breast cancer cells and 11.6 nM in MDA-MB-231 cells. This compound is valuable for research applications focused on developing targeted therapies for breast cancer and understanding the mechanisms of tumor cell resistance.
Anticancer agent 216 (34A) is a Camptothecin derivative that selectively inhibits topoisomerase I, disrupting DNA replication and transcription. It demonstrates potent cytotoxicity with IC50 values of 9.6 nM in MCF-7 breast cancer cells and 11.6 nM in MDA-MB-231 cells. This compound is valuable for research applications focused on developing targeted therapies for breast cancer and understanding the mechanisms of tumor cell resistance.
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