Anxiolytic/Nonsedative Agent-1 is a potent GABAA receptor agonist demonstrating selective affinity for various benzodiazepine receptors in bovine brain membranes, with inhibition constants (Kis) of 14, 121, and 239 nM for α1β2γ2, α2β2γ2, and α5β3γ2 subtypes, respectively. This compound exhibits selective efficacy for the α2 subunit in vitro and displays anxioselective effects in vivo, making it a valuable tool for research into anxiety-related disorders and potential therapeutics.
Anxiolytic/Nonsedative Agent-1 is a potent GABAA receptor agonist demonstrating selective affinity for various benzodiazepine receptors in bovine brain membranes, with inhibition constants (Kis) of 14, 121, and 239 nM for α1β2γ2, α2β2γ2, and α5β3γ2 subtypes, respectively. This compound exhibits selective efficacy for the α2 subunit in vitro and displays anxioselective effects in vivo, making it a valuable tool for research into anxiety-related disorders and potential therapeutics.
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