AP1903

Catalog No.: A13519

AP1903 Chemical Structure

CAS NO. 195514-63-7

AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$510.00
25 mg
$980.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 7.08 mL 35.42 mL 70.84 mL
0.5 mM 1.42 mL 7.08 mL 14.17 mL
1 mM 0.71 mL 3.54 mL 7.08 mL
5 mM 0.14 mL 0.71 mL 1.42 mL

*The above data is based on the productmolecular weight 1411.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13519
Actions No
M. Wt 1411.63
Formula C78H98N4O20
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 195514-63-7
Synonyms AP 1903, AP-1903
SMILES CC[[email protected]@H](C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCC[[email protected]]2C(=O)O[[email protected]](CCC3=CC(=C(C=C3)OC)OC)C4=CC(=CC=C4)OCC(=O)NCCNC(=O)COC5=CC=CC(=C5)[[email protected]@H](CCC6=CC(=C(C=C6)OC)OC)OC(=O)[[email protected]@H]7CCCCN7C(=O)[[email protected]@H](CC)C8=CC(=C(C(=C8)OC)OC)OC

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy AP1903 | AP1903 Supplier | purchase AP1903 | AP1903 cost | AP1903 manufacturer | order AP1903 | AP1903 distributor | buy 195514-63-7| 195514-63-7 Supplier | purchase 195514-63-7 | 195514-63-7 cost | 195514-63-7 manufacturer | order 195514-63-7 | 195514-63-7 distributor
Rewards