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AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 7.08 mL | 35.42 mL | 70.84 mL |
| 0.5 mM | 1.42 mL | 7.08 mL | 14.17 mL |
| 1 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 5 mM | 0.14 mL | 0.71 mL | 1.42 mL |
*The above data is based on the productmolecular weight 1411.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13519 |
|---|---|
| M. Wt | 1411.63 |
| Formula | C78H98N4O20 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 195514-63-7 |
| Synonyms | AP 1903, AP-1903 |
| SMILES | CC[[email protected]@H](C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCC[[email protected]]2C(=O)O[[email protected]](CCC3=CC(=C(C=C3)OC)OC)C4=CC(=CC=C4)OCC(=O)NCCNC(=O)COC5=CC=CC(=C5)[[email protected]@H](CCC6=CC(=C(C=C6)OC)OC)OC(=O)[[email protected]@H]7CCCCN7C(=O)[[email protected]@H](CC)C8=CC(=C(C(=C8)OC)OC)OC |
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