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Apoptosis Activator 2

Apoptosis Activator

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Catalog No. A11944

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Apoptosis Activator 2 10mg A11944-10
€47.50
Apoptosis Activator 2 25mg A11944-25
€104.50
Apoptosis Activator 2 50mg A11944-50
€171.00
Apoptosis Activator 2 100mg A11944-100
€270.75
Apoptosis Activator 2 10mM * 1mL in DMSO A11944-10mM-D
€52.25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells

Apoptosis Activator 2

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Chemical Information

Catalog Num A11944
Actions Activator
M. Wt 306.1
Formula C15H9Cl2NO2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 79183-19-0
Synonyms N/A
SMILES C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl

Biological Activity

Description
 Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells
Targets
Caspase-3

Solubility

Solubility (25°C)* In vitro DMSO 61 mg/mL (199.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.67 mL 163.35 mL 326.69mL
0.5 mM 6.53 mL 32.67 mL 65.34 mL
1 mM 3.27 mL 16.33 mL 32.67 mL
5 mM 0.65 mL 3.27 mL 6.53 mL

*The above data is based on the productmolecular weight 306.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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