Apremilast-d3 is a deuterated form of Apremilast, an orally bioavailable inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. By inhibiting PDE-4, Apremilast-d3 effectively reduces the release of TNF-α in response to lipopolysaccharide (LPS), exhibiting an IC50 of 104 nM. This stable isotope-labeled reagent is valuable for quantitative studies in pharmacokinetics and metabolic research related to inflammatory conditions.
Apremilast-d3 is a deuterated form of Apremilast, an orally bioavailable inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. By inhibiting PDE-4, Apremilast-d3 effectively reduces the release of TNF-α in response to lipopolysaccharide (LPS), exhibiting an IC50 of 104 nM. This stable isotope-labeled reagent is valuable for quantitative studies in pharmacokinetics and metabolic research related to inflammatory conditions.
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