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APX-115 free base

Catalog No.: A22055

NADPH oxidase inhibitor

APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively.
APX-115 free base 1270084-92-8 <p>NADPH oxidase inhibitor</p>
Grouped product items
Size Price Stock Qty
1mg
$35.00
In stock
5mg
$90.00
In stock
10mg
$155.00
In stock
25mg
$340.00
In stock
50mg
$555.00
In stock
100mg
$860.00
In stock
200mg
$1,185.00
In stock
10mM * 1mL in DMSO
$120.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
Data Sheet SDS

Other Forms of APX-115 free base

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAPX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively.
Product Information
Catalog NumA22055
FormulaC17H17N3O
Molecular Weight279.34
CAS Number1270084-92-8
SMILESOC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3
SynonymsEwha-18278 free base
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

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    V2

Immunology & Inflammation > NADPH oxidase