AR Antagonist 10 is a potent androgen receptor (AR) antagonist that demonstrates an IC50 value of 0.04 μM. It employs dual mechanisms of action by disrupting AR dimerization and promoting AR degradation through the ubiquitin-proteasome pathway. This compound shows significant efficacy against drug-resistant AR variants and effectively inhibits tumor growth in LNCaP xenograft models. AR Antagonist 10 has potential applications in the treatment of drug-resistant prostate cancer.
AR Antagonist 10 is a potent androgen receptor (AR) antagonist that demonstrates an IC50 value of 0.04 μM. It employs dual mechanisms of action by disrupting AR dimerization and promoting AR degradation through the ubiquitin-proteasome pathway. This compound shows significant efficacy against drug-resistant AR variants and effectively inhibits tumor growth in LNCaP xenograft models. AR Antagonist 10 has potential applications in the treatment of drug-resistant prostate cancer.
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