AR Antagonist 12 is a potent androgen receptor (AR) antagonist that selectively targets wild-type AR and the AR-F877L variant, demonstrating IC50 values of 119.3 μM and 98.2 μM, respectively. This compound effectively reduces the protein levels of AR, AR-V7, and PSA in a dose-dependent and time-dependent manner, showcasing its therapeutic potential. AR Antagonist 12 is particularly useful for investigating resistance mechanisms in prostate cancer, including studies related to Enzalutamide responsiveness.
AR Antagonist 12 is a potent androgen receptor (AR) antagonist that selectively targets wild-type AR and the AR-F877L variant, demonstrating IC50 values of 119.3 μM and 98.2 μM, respectively. This compound effectively reduces the protein levels of AR, AR-V7, and PSA in a dose-dependent and time-dependent manner, showcasing its therapeutic potential. AR Antagonist 12 is particularly useful for investigating resistance mechanisms in prostate cancer, including studies related to Enzalutamide responsiveness.
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