ARC 239 dihydrochloride is a selective antagonist of the α2B and α2C adrenoceptors, demonstrating pKd values of 5.95, 7.41, and 7.56 at the α2A, α2B, and α2C receptors, respectively. This compound effectively binds to CHO cell membranes expressing human recombinant α2A, α2B, and α2C adrenoceptor subtypes, showing pKi values of 5.6, 8.4, and 7.08. ARC 239 dihydrochloride is valuable for research applications in studying adrenergic signaling pathways and the physiological roles of α2 adrenergic receptors.
ARC 239 dihydrochloride is a selective antagonist of the α2B and α2C adrenoceptors, demonstrating pKd values of 5.95, 7.41, and 7.56 at the α2A, α2B, and α2C receptors, respectively. This compound effectively binds to CHO cell membranes expressing human recombinant α2A, α2B, and α2C adrenoceptor subtypes, showing pKi values of 5.6, 8.4, and 7.08. ARC 239 dihydrochloride is valuable for research applications in studying adrenergic signaling pathways and the physiological roles of α2 adrenergic receptors.
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