ARD-2051 is a selective and orally active degrader targeting the androgen receptor (AR) via a proteolysis-targeting chimera approach. It demonstrates potent DC50 values of 0.6 nM for AR degradation in prostate cancer cell lines such as LNCaP and VCaP. ARD-2051 exhibits significant anti-tumor efficacy in VCaP xenograft mouse models, making it a valuable tool for prostate cancer research and therapeutic exploration.
ARD-2051 is a selective and orally active degrader targeting the androgen receptor (AR) via a proteolysis-targeting chimera approach. It demonstrates potent DC50 values of 0.6 nM for AR degradation in prostate cancer cell lines such as LNCaP and VCaP. ARD-2051 exhibits significant anti-tumor efficacy in VCaP xenograft mouse models, making it a valuable tool for prostate cancer research and therapeutic exploration.
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