ARD-266 is a potent PROTAC degrader targeting the Androgen Receptor (AR) through a von Hippel-Lindau E3 ligase mechanism. It effectively induces AR protein degradation in AR-positive prostate cancer cell lines, including LNCaP, VCaP, and 22Rv1, with DC50 values ranging from 0.2 to 1 nM. Additionally, ARD-266 features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating versatile applications in chemical biology research.
ARD-266 is a potent PROTAC degrader targeting the Androgen Receptor (AR) through a von Hippel-Lindau E3 ligase mechanism. It effectively induces AR protein degradation in AR-positive prostate cancer cell lines, including LNCaP, VCaP, and 22Rv1, with DC50 values ranging from 0.2 to 1 nM. Additionally, ARD-266 features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating versatile applications in chemical biology research.
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