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ARRY334543 (Varlitinib)

EGFR inhibitor

158 Customer Reviews
Catalog No. A11158

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ARRY334543 5mg A11158-5
$120.00
ARRY334543 10mg A11158-10
$190.00
ARRY334543 50mg A11158-50
$470.00
ARRY334543 200mg A11158-200
$1,860.00
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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ARRY334543 is a potent, orally active small molecule inhibitor of EGFR and ErbB-2.

ARRY334543 (Varlitinib)

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Chemical Information

Catalog Num A11158
Actions Inhibitor
M. Wt 466.94
Formula C22H19ClN6O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 845272-21-1
Synonyms ARRY-334543, Varlitinib
SMILES C1=CC=C(C=C1)C[N+]2=C(N=C(S2)NC3=CC=CC=C3)C4=CC=CC=C4

Biological Activity

Description
 ARRY334543 is a potent, orally active small molecule inhibitor of EGFR and ErbB-2.

Solubility

Solubility (25°C)* In vitro DMSO 6 mg/mL (12.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.42 mL 107.08 mL 214.16mL
0.5 mM 4.28 mL 21.42 mL 42.83 mL
1 mM 2.14 mL 10.71 mL 21.42 mL
5 mM 0.43 mL 2.14 mL 4.28 mL

*The above data is based on the productmolecular weight 466.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
A11022 AG-1478 (Tyrphostin AG-1478) <1 mg/mL 25 mg/mL 13 mg/mL
A10047 AG 490 <1 mg/mL 59 mg/mL 6 mg/mL
A11027 ARRY-380 <1 mg/mL 114 mg/mL <1 mg/mL
A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
A11155 AST-1306 <1 mg/mL 124 mg/mL <1 mg/mL
A10116 AZD8931 <1 mg/mL 40 mg/mL <1 mg/mL
A11334 BIBX 1382 50 mg/mL 50 mg/mL N/A
A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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