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ARRY334543 (Varlitinib)

Catalog No.: A11158

EGFR inhibitor

ARRY334543 (Varlitinib)

ARRY334543 (Varlitinib) Chemical Structure

CAS NO. 845272-21-1

ARRY334543 is a potent, orally active small molecule inhibitor of EGFR and ErbB-2.

Availability: In stock

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5 mg

Regular Price: $120.00

Special Price $96.00

10 mg

Regular Price: $190.00

Special Price $152.00

50 mg

Regular Price: $470.00

Special Price $376.00

200 mg

Regular Price: $1,860.00

Special Price $1,488.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259

Biological Activity

ARRY334543 is a potent, orally active small molecule inhibitor of EGFR and ErbB-2.
In vitro DMSO 6 mg/mL (12.84 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.42 mL 107.08 mL 214.16 mL
0.5 mM 4.28 mL 21.42 mL 42.83 mL
1 mM 2.14 mL 10.71 mL 21.42 mL
5 mM 0.43 mL 2.14 mL 4.28 mL

*The above data is based on the productmolecular weight 466.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11158
Actions Inhibitor
CAS No. 845272-21-1
Formula C22H19ClN6O2S
M. Wt 466.94
Purity >98%
Synonyms ARRY-334543, Varlitinib
SMILES C[[email protected]@H]1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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