ARRY334543 (Varlitinib)

Catalog No.: A11158

EGFR inhibitor

ARRY334543 (Varlitinib)

ARRY334543 (Varlitinib) Chemical Structure

CAS NO. 845272-21-1

ARRY334543 is a potent, orally active small molecule inhibitor of EGFR and ErbB-2.

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  • Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259

Biological Activity

ARRY334543 is a potent, orally active small molecule inhibitor of EGFR and ErbB-2.
In vitro DMSO 6 mg/mL (12.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.42 mL 107.08 mL 214.16 mL
0.5 mM 4.28 mL 21.42 mL 42.83 mL
1 mM 2.14 mL 10.71 mL 21.42 mL
5 mM 0.43 mL 2.14 mL 4.28 mL

*The above data is based on the productmolecular weight 466.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11158
Actions Inhibitor
M. Wt 466.94
Formula C22H19ClN6O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 845272-21-1
Synonyms ARRY-334543, Varlitinib

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