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- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
Biological Activity
ARRY334543 is a potent, orally active small molecule inhibitor of EGFR and ErbB-2.
| In vitro | DMSO | 6 mg/mL (12.84 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.42 mL | 107.08 mL | 214.16 mL |
| 0.5 mM | 4.28 mL | 21.42 mL | 42.83 mL |
| 1 mM | 2.14 mL | 10.71 mL | 21.42 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.28 mL |
*The above data is based on the productmolecular weight 466.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11158 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 845272-21-1 |
| Formula | C22H19ClN6O2S |
| M. Wt | 466.94 |
| Purity | >98% |
| Synonyms | ARRY-334543, Varlitinib |
| SMILES | C[[email protected]@H]1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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