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Biological Activity
AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively.
Targets
| Casein Kinase 2 (Cell-free assay) | PI3Kγ (Cell-free assay) | PI3Kα (Cell-free assay) | ||
| 20 nM | 33 nM | 935 nM |
| In vitro (25°C) | DMSO | 57 mg/mL (186.71 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 4% DMSO+50% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.75 mL | 163.77 mL | 327.55 mL |
| 0.5 mM | 6.55 mL | 32.75 mL | 65.51 mL |
| 1 mM | 3.28 mL | 16.38 mL | 32.75 mL |
| 5 mM | 0.66 mL | 3.28 mL | 6.55 mL |
*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11099 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 900515-16-4 |
| Formula | C14H8FNO4S |
| M. Wt | 305.3 |
| Purity | >98% |
| Synonyms | AS252424 |
| SMILES | C1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C\3/C(=O)NC(=O)S3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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