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AS-252424

Catalog No.: A11099

PI3K inhibitor

AS-252424

AS-252424 Chemical Structure

CAS NO. 900515-16-4

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$100.00
50 mg
$400.00
100 mg
$650.00
10mM * 1mL in DMSO
$96.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively.
Targets
Casein Kinase 2 (Cell-free assay) PI3Kγ (Cell-free assay) PI3Kα (Cell-free assay)
20 nM33 nM935 nM
In vitro (25°C) DMSO 57 mg/mL (186.71 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+50% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.75 mL 163.77 mL 327.55 mL
0.5 mM 6.55 mL 32.75 mL 65.51 mL
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL

*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11099
Actions Inhibitor
CAS No. 900515-16-4
Formula C14H8FNO4S
M. Wt 305.3
Purity >98%
Synonyms AS252424
SMILES C1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C\3/C(=O)NC(=O)S3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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