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Biological Activity
AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively.
Targets
Casein Kinase 2 (Cell-free assay) | PI3Kγ (Cell-free assay) | PI3Kα (Cell-free assay) | ||
20 nM | 33 nM | 935 nM |
In vitro (25°C) | DMSO | 57 mg/mL (186.71 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 4% DMSO+50% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 32.75 mL | 163.77 mL | 327.55 mL |
0.5 mM | 6.55 mL | 32.75 mL | 65.51 mL |
1 mM | 3.28 mL | 16.38 mL | 32.75 mL |
5 mM | 0.66 mL | 3.28 mL | 6.55 mL |
*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11099 |
---|---|
Actions | Inhibitor |
CAS No. | 900515-16-4 |
Formula | C14H8FNO4S |
M. Wt | 305.3 |
Purity | >98% |
Synonyms | AS252424 |
SMILES | C1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C\3/C(=O)NC(=O)S3 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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