AS1842856

Catalog No.: A15871

Foxo1 Inhibitor

AS1842856

AS1842856 Chemical Structure

CAS NO. 836620-48-5

AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form.

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10 mg

Regular Price: $80.00

Special Price $64.00

25 mg

Regular Price: $130.00

Special Price $104.00

50 mg

Regular Price: $175.00

Special Price $140.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Zhongsheng Zhu, .et al. Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway, BMC Complement Altern Med, 2019, 19: 111 PMID: 31146723

Biological Activity

AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form.
Targets
Foxo1
33nM
In vitro DMSO 23 mg/mL (66.2 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.79 mL 143.93 mL 287.87 mL
0.5 mM 5.76 mL 28.79 mL 57.57 mL
1 mM 2.88 mL 14.39 mL 28.79 mL
5 mM 0.58 mL 2.88 mL 5.76 mL

*The above data is based on the productmolecular weight 347.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15871
Actions Inhibitor
CAS No. 836620-48-5
Formula C18H22FN3O3
M. Wt 347.38
Purity >98%
Synonyms AS 1842856, AS-1842856
SMILES O=C1C(C(O)=O)=CN(CC)C2=C1C(N)=C(F)C(NC3CCCCC3)=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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