Aselacin A is an endothelin-1 receptor (ET-1 receptor) antagonist that effectively inhibits the binding of endothelin-1 to both ETA and ETB receptors. Demonstrating IC50 values of 22 μg/mL and 20 μg/mL, it inhibits ET-1 binding to bovine atrial and porcine cerebral membranes, respectively. This compound is valuable for research into cardiovascular diseases and exploring the pathological roles of endothelin signaling in various cardiovascular conditions.
Aselacin A is an endothelin-1 receptor (ET-1 receptor) antagonist that effectively inhibits the binding of endothelin-1 to both ETA and ETB receptors. Demonstrating IC50 values of 22 μg/mL and 20 μg/mL, it inhibits ET-1 binding to bovine atrial and porcine cerebral membranes, respectively. This compound is valuable for research into cardiovascular diseases and exploring the pathological roles of endothelin signaling in various cardiovascular conditions.
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