Aselacin B

Catalog No.: A60290
ET Receptor Antagonist
Aselacin B is an endothelin-1 receptor antagonist that inhibits the binding of endothelin-1 to both ETA and ETB receptors. This compound plays a significant role in the investigation of cardiovascular diseases by modulating endothelin signaling pathways. Its application may provide insights into the pathophysiology of conditions such as hypertension and heart failure.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAselacin B is an endothelin-1 receptor antagonist that inhibits the binding of endothelin-1 to both ETA and ETB receptors. This compound plays a significant role in the investigation of cardiovascular diseases by modulating endothelin signaling pathways. Its application may provide insights into the pathophysiology of conditions such as hypertension and heart failure.
Product Information
Catalog NumA60290
FormulaC46H66N8O12
Molecular Weight923.06
CAS Number156223-07-3
SMILESO=C1O[C@@H]([C@@H](C(NCCC(N[C@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](CO)C(NC1)=O)=O)=O)=O)NC(C(CCC(N)=O)NC(CCCCCCCC(/C=C/C=C/CCCC(C)O)=O)=O)=O)C
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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