ASP9436 is a potent and orally available inhibitor of phosphodiesterase 10A (PDE10A), exhibiting an IC50 of 8 nM against human PDE10A. This compound effectively reduces locomotor activity in mouse models of hyperactivity and improves visual recognition memory deficits in neonatal mice. ASP9436 is valuable for research focused on understanding and potentially treating schizophrenia.
ASP9436 is a potent and orally available inhibitor of phosphodiesterase 10A (PDE10A), exhibiting an IC50 of 8 nM against human PDE10A. This compound effectively reduces locomotor activity in mouse models of hyperactivity and improves visual recognition memory deficits in neonatal mice. ASP9436 is valuable for research focused on understanding and potentially treating schizophrenia.
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