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aStAx-35R

Catalog No.: A37101
β-Catenin Antagonist
aStAx-35R is a stapled peptide that functions as a β-catenin antagonist targeting the nuclear form of β-catenin to disrupt Wnt signaling pathways. By competitively inhibiting the binding of β-catenin to TCF4, aStAx-35R effectively induces growth inhibition in Wnt-dependent cancer cell lines. This compound presents valuable potential for research applications focused on cancer biology and therapeutic strategies targeting the Wnt/β-catenin signaling pathway.
aStAx-35R 1418863-17-8 β-Catenin Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionaStAx-35R is a stapled peptide that functions as a β-catenin antagonist targeting the nuclear form of β-catenin to disrupt Wnt signaling pathways. By competitively inhibiting the binding of β-catenin to TCF4, aStAx-35R effectively induces growth inhibition in Wnt-dependent cancer cell lines. This compound presents valuable potential for research applications focused on cancer biology and therapeutic strategies targeting the Wnt/β-catenin signaling pathway.
Product Information
Catalog NumA37101
FormulaC111H178N40O20
Molecular Weight2392.86
CAS Number1418863-17-8
SequenceAc-Arg-Arg-Trp-Pro-Arg-S5-Ile-Leu-Asp-S5-His-Val-Arg-Arg-Val-Trp-Arg-NH2
Sequence shorteningAc-RRWPR-S5-ILD-S5-HVRRVWR-NH2
SMILESC([C@@H](C(=O)N1[C@H](C(N[C@H](C(N[C@]2(C)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)=O)C(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)[C@@H](C)C)=O)=O)(C)CCCC=CCCC2)[H])=O)CCCNC(=N)N)=O)CCC1)NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CCCNC(=N)N)=O)C=6C=7C(NC6)=CC=CC7
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Stem Cells/Wnt > β-catenin