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- Mahim Khan, .et al. Hesperidin identified from Citrus extracts potently inhibits HCV genotype 3a NS3 protease, BMC Complement Med Ther, 2022, Apr 2;22(1):98 PMID: 35366855
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- Kato N, .et al. Study of multiple genetic variations caused by persistent hepatitis C virus replication in long-term cell culture, Arch Virol, 2019, Dec 12 PMID: 31832864
- Fay EJ, .et al. Engineered Small-Molecule Control of Influenza A Virus Replication, J Virol, 2018, Fay EJ PMID: 30282710
- Bennie Lemmens, .et al. DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation, Mol Cell, 2018, Jul 5; 71(1): 117-128.e3 PMID: 30008317
- Ueda Y, .et al. Evaluation of preclinical antimalarial drugs, which can overcome direct-acting antivirals-resistant hepatitis C viruses, using the viral reporter assay systems, Virus Res, 2017, May 2;235:37-48 PMID: 28322919
- Furihata T, .et al. Differential inhibition features of direct-acting anti-hepatitis C virus agents against human organic anion transporting polypeptide 2B1, Int J Antimicrob Agents, 2015, Oct;46(4):381-8 PMID: 26163159
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Biological Activity
Asunaprevir is an inhibitor of the viral enzyme serine protease NS3.
In vitro | DMSO | 89 mg/mL (118.93 mM) | |
Water | Insoluble | ||
Ethanol | 89 mg/mL | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 13.36 mL | 66.82 mL | 133.64 mL |
0.5 mM | 2.67 mL | 13.36 mL | 26.73 mL |
1 mM | 1.34 mL | 6.68 mL | 13.36 mL |
5 mM | 0.27 mL | 1.34 mL | 2.67 mL |
*The above data is based on the productmolecular weight 748.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11295 |
---|---|
Actions | Inhibitor |
CAS No. | 630420-16-5 |
Formula | C35H46ClN5O9S |
M. Wt | 748.3 |
Purity | >98% |
Synonyms | BMS650032, ASV |
SMILES | O=C(N[[email protected]@]1(C(NS(C2CC2)(=O)=O)=O)[[email protected]](C=C)C1)[[email protected]]3N(C([[email protected]](C(C)(C)C)NC(OC(C)(C)C)=O)=O)C[[email protected]@H](OC4=C(C=C(Cl)C=C5)C5=C(OC)C=N4)C3 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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