Asunaprevir (BMS-650032)

Name: Asunaprevir (BMS-650032)
Brand: Adooq Bioscience
SKU: A11295
Rating: 100 (8 reviews)

Catalog No.: A11295

NS3 protease inhibitor

Product Citations (8)

Asunaprevir (BMS-650032) Chemical Structure

CAS NO. 630420-16-5

Asunaprevir is an inhibitor of the viral enzyme serine protease NS3.

Availability: In stock

Package	Price	Qty
5 mg	$180.00
10 mg	$300.00
25 mg	$550.00
50 mg	$850.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Asunaprevir (BMS-650032)

Mahim Khan, .et al. Hesperidin identified from Citrus extracts potently inhibits HCV genotype 3a NS3 protease, BMC Complement Med Ther, 2022, Apr 2;22(1):98 PMID: 35366855
Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467
Kato N, .et al. Study of multiple genetic variations caused by persistent hepatitis C virus replication in long-term cell culture, Arch Virol, 2019, Dec 12 PMID: 31832864
Fay EJ, .et al. Engineered Small-Molecule Control of Influenza A Virus Replication, J Virol, 2018, Fay EJ PMID: 30282710
Bennie Lemmens, .et al. DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation, Mol Cell, 2018, Jul 5; 71(1): 117-128.e3 PMID: 30008317
Ueda Y, .et al. Evaluation of preclinical antimalarial drugs, which can overcome direct-acting antivirals-resistant hepatitis C viruses, using the viral reporter assay systems, Virus Res, 2017, May 2;235:37-48 PMID: 28322919
Furihata T, .et al. Differential inhibition features of direct-acting anti-hepatitis C virus agents against human organic anion transporting polypeptide 2B1, Int J Antimicrob Agents, 2015, Oct;46(4):381-8 PMID: 26163159
Tomomi Furihata, .et al. Different Interaction Profiles of Direct-Acting Anti-Hepatitis C Virus Agents with Human Organic Anion Transporting Polypeptides, Antimicrob Agents Chemother, 2014, 58(8): 4555-4564 PMID: 24867984

Biological Activity

Asunaprevir is an inhibitor of the viral enzyme serine protease NS3.

Solubility *

In vitro	DMSO	89 mg/mL (118.93 mM)
	Water	Insoluble
	Ethanol	89 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.36 mL	66.82 mL	133.64 mL
0.5 mM	2.67 mL	13.36 mL	26.73 mL
1 mM	1.34 mL	6.68 mL	13.36 mL
5 mM	0.27 mL	1.34 mL	2.67 mL

*The above data is based on the productmolecular weight 748.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11295
Actions	Inhibitor
CAS No.	630420-16-5
Formula	C35H46ClN5O9S
M. Wt	748.3
Purity	>98%
Synonyms	BMS650032, ASV
SMILES	O=C(N[[email protected]@]1(C(NS(C2CC2)(=O)=O)=O)[[email protected]](C=C)C1)[[email protected]]3N(C([[email protected]](C(C)(C)C)NC(OC(C)(C)C)=O)=O)C[[email protected]@H](OC4=C(C=C(Cl)C=C5)C5=C(OC)C=N4)C3
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.