Asunaprevir (BMS-650032)

Catalog No.: A11295

NS3 protease inhibitor

Asunaprevir (BMS-650032)

Asunaprevir (BMS-650032) Chemical Structure

CAS NO. 630420-16-5

Asunaprevir is an inhibitor of the viral enzyme serine protease NS3.

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5 mg
$180.00
10 mg
$300.00
25 mg
$550.00
50 mg
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  • Kato N, .et al. Study of multiple genetic variations caused by persistent hepatitis C virus replication in long-term cell culture, Arch Virol, 2019, Dec 12 PMID: 31832864
  • Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467
  • Fay EJ, .et al. Engineered Small-Molecule Control of Influenza A Virus Replication, J Virol, 2018, Fay EJ PMID: 30282710
  • Bennie Lemmens, .et al. DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation, Mol Cell, 2018, Jul 5; 71(1): 117-128.e3 PMID: 30008317
  • Ueda Y, .et al. Evaluation of preclinical antimalarial drugs, which can overcome direct-acting antivirals-resistant hepatitis C viruses, using the viral reporter assay systems, Virus Res, 2017, May 2;235:37-48 PMID: 28322919
  • Furihata T, .et al. Differential inhibition features of direct-acting anti-hepatitis C virus agents against human organic anion transporting polypeptide 2B1, Int J Antimicrob Agents, 2015, Oct;46(4):381-8 PMID: 26163159
  • Tomomi Furihata, .et al. Different Interaction Profiles of Direct-Acting Anti-Hepatitis C Virus Agents with Human Organic Anion Transporting Polypeptides, Antimicrob Agents Chemother, 2014, 58(8): 4555-4564. PMID: 24867984

Biological Activity

Asunaprevir is an inhibitor of the viral enzyme serine protease NS3.
In vitro DMSO 89 mg/mL (118.93 mM)
Water Insoluble
Ethanol 89 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.36 mL 66.82 mL 133.64 mL
0.5 mM 2.67 mL 13.36 mL 26.73 mL
1 mM 1.34 mL 6.68 mL 13.36 mL
5 mM 0.27 mL 1.34 mL 2.67 mL

*The above data is based on the productmolecular weight 748.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11295
Actions Inhibitor
CAS No. 630420-16-5
Formula C35H46ClN5O9S
M. Wt 748.3
Purity >98%
Synonyms BMS650032, ASV
SMILES O=C(N[[email protected]@]1(C(NS(C2CC2)(=O)=O)=O)[[email protected]](C=C)C1)[[email protected]]3N(C([[email protected]](C(C)(C)C)NC(OC(C)(C)C)=O)=O)C[[email protected]@H](OC4=C(C=C(Cl)C=C5)C5=C(OC)C=N4)C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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