AT7867

Catalog No.: A10094

AKT inhibitor

AT7867 Chemical Structure

CAS NO. 857531-00-1

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.

Availability: In stock

Package Price Qty
10 mg
$150.00
25 mg
$350.00
50 mg
$600.00
100 mg
$950.00
10mM * 1mL in DMSO
$147.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
Targets
Target Value
Akt2IC50: 17nM
PKAIC50: 20nM
Akt1IC50: 32nM
Akt3IC50: 47nM
p70S6KIC50: 85nM
RSK1IC50: >100nM
CDK2IC50: >1μM
GSK-3βIC50: >1μM
c-SrcIC50: >1μM
Chk1IC50: >1μM
EGFRIC50: >1μM
FGFR3IC50: >1μM
MEK1IC50: >1μM
PDK-1IC50: >1μM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
Tie-2IC50: >1μM
In vitro (25°C) DMSO 68 mg/mL (201.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (14.79 mM)
In vivo 15% Captisol, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.59 mL 147.97 mL 295.95 mL
0.5 mM 5.92 mL 29.59 mL 59.19 mL
1 mM 2.96 mL 14.8 mL 29.59 mL
5 mM 0.59 mL 2.96 mL 5.92 mL

*The above data is based on the productmolecular weight 337.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10094
Actions Inhibitor
M. Wt 337.9
Formula C20H20ClN3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 857531-00-1
Synonyms AT-7867
SMILES C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl

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