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AKT inhibitor

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Catalog No. A10094

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AT7867 10mg A10094-10
AT7867 25mg A10094-25
AT7867 50mg A10094-50
AT7867 100mg A10094-100
AT7867 10mM * 1mL in DMSO A10094-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.


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Chemical Information

Catalog Num A10094
Actions Inhibitor
M. Wt 337.9
Formula C20H20ClN3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 857531-00-1
Synonyms AT-7867

Biological Activity

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
Target Value
Akt2IC50: 17nM
PKAIC50: 20nM
Akt1IC50: 32nM
Akt3IC50: 47nM
p70S6KIC50: 85nM
RSK1IC50: >100nM
CDK2IC50: >1μM
GSK-3βIC50: >1μM
c-SrcIC50: >1μM
Chk1IC50: >1μM
EGFRIC50: >1μM
FGFR3IC50: >1μM
MEK1IC50: >1μM
PDK-1IC50: >1μM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
Tie-2IC50: >1μM


Solubility (25°C) * In vitro DMSO 68 mg/mL (201.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (14.79 mM)
In vivo 15% Captisol, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.59 mL 147.97 mL 295.95mL
0.5 mM 5.92 mL 29.59 mL 59.19 mL
1 mM 2.96 mL 14.8 mL 29.59 mL
5 mM 0.59 mL 2.96 mL 5.92 mL

*The above data is based on the productmolecular weight 337.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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