Biological Activity
AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
Targets
Target | Value |
---|---|
Akt2 | IC50: 17nM |
PKA | IC50: 20nM |
Akt1 | IC50: 32nM |
Akt3 | IC50: 47nM |
p70S6K | IC50: 85nM |
RSK1 | IC50: >100nM |
CDK2 | IC50: >1μM |
GSK-3β | IC50: >1μM |
c-Src | IC50: >1μM |
Chk1 | IC50: >1μM |
EGFR | IC50: >1μM |
FGFR3 | IC50: >1μM |
MEK1 | IC50: >1μM |
PDK-1 | IC50: >1μM |
PI3Kβ | IC50: >1μM |
PLK3 | IC50: >1μM |
RET | IC50: >1μM |
SGK | IC50: >1μM |
Tie-2 | IC50: >1μM |
In vitro (25°C) | DMSO | 68 mg/mL (201.27 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | 5 mg/mL (14.79 mM) | ||
In vivo | 15% Captisol, pH 9 | 10 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 29.59 mL | 147.97 mL | 295.95 mL |
0.5 mM | 5.92 mL | 29.59 mL | 59.19 mL |
1 mM | 2.96 mL | 14.8 mL | 29.59 mL |
5 mM | 0.59 mL | 2.96 mL | 5.92 mL |
*The above data is based on the productmolecular weight 337.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10094 |
---|---|
Actions | Inhibitor |
M. Wt | 337.9 |
Formula | C20H20ClN3 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 857531-00-1 |
Synonyms | AT-7867 |
SMILES | C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl |
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