AT7867

Name: AT7867
Brand: Adooq Bioscience
SKU: A10094
Rating: 100 (268 reviews)

Catalog No.: A10094

AKT inhibitor

AT7867 Chemical Structure

CAS NO. 857531-00-1

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.

Availability: In stock

Package	Price	Qty
10 mg	$150.00
25 mg	$350.00
50 mg	$600.00
100 mg	$950.00
10mM * 1mL in DMSO	$147.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Biological Activity

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.

Targets

Target	Value
Akt2	IC50: 17nM
PKA	IC50: 20nM
Akt1	IC50: 32nM
Akt3	IC50: 47nM
p70S6K	IC50: 85nM
RSK1	IC50: >100nM
CDK2	IC50: >1μM
GSK-3β	IC50: >1μM
c-Src	IC50: >1μM
Chk1	IC50: >1μM
EGFR	IC50: >1μM
FGFR3	IC50: >1μM
MEK1	IC50: >1μM
PDK-1	IC50: >1μM
PI3Kβ	IC50: >1μM
PLK3	IC50: >1μM
RET	IC50: >1μM
SGK	IC50: >1μM
Tie-2	IC50: >1μM

Solubility *

In vitro (25°C)	DMSO	63 mg/mL (186.47 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (14.79 mM)
In vivo	15% Captisol, pH 9	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.59 mL	147.97 mL	295.95 mL
0.5 mM	5.92 mL	29.59 mL	59.19 mL
1 mM	2.96 mL	14.8 mL	29.59 mL
5 mM	0.59 mL	2.96 mL	5.92 mL

*The above data is based on the productmolecular weight 337.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10094
Actions	Inhibitor
CAS No.	857531-00-1
Formula	C20H20ClN3
M. Wt	337.9
Purity	>98%
Synonyms	AT-7867
SMILES	C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.