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- Cole Schonhofer, .et al. Flavonoid-based inhibition of cyclin-dependent kinase 9 without concomitant inhibition of histone deacetylases durably reinforces HIV latency, Biochem Pharmacol, 2021, Apr;186:114462 PMID: 33577894
Biological Activity
Atuveciclib, also known as BAY1143572, is a highly selective, potent and orally available inhibitor of PTEFb/CDK9 currently in Phase I.
| In vitro | DMSO | 69 mg/mL (178.09 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.81 mL | 129.06 mL | 258.11 mL |
| 0.5 mM | 5.16 mL | 25.81 mL | 51.62 mL |
| 1 mM | 2.58 mL | 12.91 mL | 25.81 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.16 mL |
*The above data is based on the productmolecular weight 387.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16810 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1414943-88-6 |
| Formula | C18H18FN5O2S |
| M. Wt | 387.43 |
| Purity | >98% |
| Synonyms | BAY 1143572, BAY-1143572 |
| SMILES | O=S(C)(CC1=CC=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=C1)=N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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