AUY922 (Luminespib, NVP-AUY922)

Catalog No.: A10659

HSP90 Inhibitor

AUY922 (Luminespib, NVP-AUY922)

AUY922 (Luminespib, NVP-AUY922) Chemical Structure

CAS NO. 747412-49-3

AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$70.00
25 mg
$140.00
100 mg
$350.00
10mM * 1mL in DMSO
$75.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Biological Activity

AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
Targets
HSP90α (Cell-free assay) HSP90β (Cell-free assay)
13 nM21 nM
In vitro (25°C) DMSO Warmed: 86 mg/mL (184.72 mM)
Water 29 mg/mL (62.28 mM)
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.48 mL 107.41 mL 214.82 mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10659
Actions Inhibitor
CAS No. 747412-49-3
Formula C26H31N3O5
M. Wt 465.5
Solubility DMSO
Purity >98%
Synonyms VER-52296, AUY-922
SMILES CCNC(=O)C1=C(/C(=C/2\C=C(C(=CC2=O)O)C(C)C)/ON1)C3=CC=C(C=C3)CN4CCOCC4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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