AUY922 (Luminespib, NVP-AUY922)

Catalog No.: A10659

HSP90 Inhibitor

AUY922 (Luminespib, NVP-AUY922) Chemical Structure

CAS NO. 747412-49-3

AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $40.00

Special Price $32.00

10 mg

Regular Price: $70.00

Special Price $56.00

25 mg

Regular Price: $140.00

Special Price $112.00

100 mg

Regular Price: $350.00

Special Price $280.00

10mM * 1mL in DMSO
$75.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
Targets
HSP90α (Cell-free assay) HSP90β (Cell-free assay)
13 nM21 nM
In vitro (25°C) DMSO 93 mg/mL heating (199.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol 31 mg/mL (66.58 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.48 mL 107.41 mL 214.82 mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10659
Actions Inhibitor
M. Wt 465.5
Formula C26H31N3O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 747412-49-3
Synonyms VER-52296, AUY-922
SMILES CCNC(=O)C1=C(/C(=C/2\C=C(C(=CC2=O)O)C(C)C)/ON1)C3=CC=C(C=C3)CN4CCOCC4

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