AUY922 (Luminespib, NVP-AUY922)

AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
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AUY922 5mg
Special Price $32.00 Regular Price $40.00
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AUY922 10mg
Special Price $56.00 Regular Price $70.00
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AUY922 25mg
Special Price $112.00 Regular Price $140.00
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AUY922 100mg
Special Price $280.00 Regular Price $350.00
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AUY922 (NVP-AUY922) 10mM * 1mL in DMSO
Special Price $60.00 Regular Price $75.00
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Adooq Products cited in reputable paper
Adooq's AUY922 (Luminespib, NVP-AUY922) has been cited by 2 publications
  • Haruka Wakasa, .et al. , J Mammary Gland Biol Neoplasia, 2022, Jun;27(2):155-170 PMID: 35581442
  • Hiroki Murano, .et al. , Plant Biotechnol Rep, 2017, 11:107-113
  • Biological Activity
    Discription AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
    Targets
    Target Value
    Product Information
    Catalog Num A10659
    Formula C26H31N3O5
    Molecular Weight 465.5
    CAS Number 747412-49-3
    SMILES CCNC(=O)C1=C(/C(=C/2\C=C(C(=CC2=O)O)C(C)C)/ON1)C3=CC=C(C=C3)CN4CCOCC4
    Synonyms VER-52296,
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 86 mg/mL (184.72 mM)
    Water Insoluble
    Ethanol 29 mg/mL (62.28 mM)
    In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.48 mL 107.41 mL 214.82 mL
    0.5 mM 4.3 mL 21.48 mL 42.96 mL
    1 mM 2.15 mL 10.74 mL 21.48 mL
    5 mM 0.43 mL 2.15 mL 4.3 mL
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