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Avapritinib-d3

Stable Isotope

Avapritinib-d3 is a deuterium-labeled derivative of Avapritinib, a potent and selective inhibitor of mutant kinase targets KIT and PDGFRA. It demonstrates remarkable biological activity with IC50 values of 0.27 nM and 0.24 nM for KIT D816V and PDGFRA D842V mutations, respectively. Avapritinib-d3 binds to the active conformation of these kinases, contributing to its antitumor effects, and it also inhibits the transport functions of ABCB1 and ABCG2. This stable isotope variant is useful for pharmacokinetic studies and tracer applications in chemical research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2408934-57-4
Applications	Stable Isotope
Formula	C₂₆H₂₄D₃FN₁₀
Molecular Weight	501.58
Synonyms	BLU-285-d3
SMILES	C[C@](N)(C1=CC=C(C=C1)F)C2=CN=C(N=C2)N(CC3)CCN3C4=NC=NN5C4=CC(C(C=N6)=CN6C([2H])([2H])[2H])=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.